The firm is developing treatments for NASH diseases.
MTCR is one of many firms seeking to find effective treatments for a rapidly growing disease.
I’ll provide a final opinion when we learn more details from management.
Company & Technology
San Diego, California-based Metacrine was founded to research treatments for NASH (Non Alcoholic Steato Hepatitis), which is a fast-growing disease globally.
Management is headed by president and Chief Executive Officer Preston Klassen, M.D., who has been with the firm since March 2017 and was previously EVP, Head of Research at Arena Pharmaceuticals and Chief Medical Officer at Laboratoris Sanifit S.L.
Below is a brief overview video of the NASH liver disease:
Source: American Liver Foundation
The firm’s lead candidate is MET409 and it is being developed both as a monotherapy and in combination with an anti-diabetic agent, for which it expects to begin a Phase 2a combination trial in 1H 2021 and a Phase 2a monotherapy trial 1H 2022.
Below is the current status of the company’s drug development pipeline:
Source: Company S-1 Filing
Investors in the firm have invested at least $122.5 million and include venBio, ARCH Venture Fund, Polaris Partners, New Enterprise Associates and Alexandria Venture Investments.
Market & Competition
According to a 2018 market research report by Allied Market Research, the global market for NASH treatments was valued at $1.2 billion in 2017 and is expected to reach $21.5 billion by 2025.
This represents a forecast CAGR (Compound Annual Growth Rate) of 58.4% from 2021 to 2025.
Key elements driving this expected growth are a surge in the incidence of diabetes resulting in greater risk of obtaining NASH as well as sharply increased development of treatment options amid greater awareness of the disease and its potential treatments.
Also, a breakdown of the different drug types used to treat NASH is shown below:
Major competitive vendors that provide or are developing treatments include:
Akero Therapeutics (AKRO)
CymaBay Therapeutics (CBAY)
ENYO PHarma SA
Intercept Pharmaceuticals (ICPT)
Numerous other firms
Metacrine’s recent financial results are typical of a trial stage biopharma in that they feature almost no revenue and significant R&D and G&A expenses associated with advancing its pipeline through stages of development.
Below are the company’s financial results for the past two and ½ years (Audited PCAOB for full years):
Source: Company registration statement
As of June 30, 2020, the company had $17.1 million in cash and $16.4 million in total liabilities. (Unaudited, interim)
Metacrine intends to raise $100 million in gross proceeds from an IPO of its common stock, although the final amount may be different.
No existing shareholders have indicated an interest to purchase shares at the IPO price, although this element may become a feature of the IPO if disclosed in a future filing.
Management says it will use the net proceeds from the IPO as follows:
to fund our planned MET409 Phase 2a combination clinical trial in NASH through completion;
to fund our planned MET642 Phase 2a monotherapy clinical trial in NASH through completion;
to fund a Phase 2a monotherapy clinical trial of either MET409 or MET642 in UC through initial partial enrollment;
to fund a Phase 2b monotherapy clinical trial of either MET409 or MET642 in NASH through initial partial enrollment; and
the remainder to fund any potential future clinical trials and preclinical programs, and for working capital and other general corporate purposes, including the additional costs associated with being a public company.
Management’s presentation of the company roadshow is not available.
Listed bookrunners of the IPO are Jefferies, Evercore ISI, RBC Capital Markets and Canaccord Genuity.
Metacrine is seeking US public capital market investment to advance its pipeline of NASH treatments into phase 2 efficacy trials.
The firm’s lead candidate is being developed as both a monotherapy and a combination agent, with Phase 2 trials expected to begin in early 2021 and 2022.
The market opportunity for developing treatments for NASH is large and expected to grow at an extremely high rate over the coming decades.
As a result, there are many, many competitors developing competing treatments oh, so the firm is one among a large cohort of early, mid and late stage firms seeking to provide effective treatments.
The firm previously had a collaboration with Novo Nordisk, where it received a nominal amount of collaboration revenue, but that collaboration concluded.
The company’s investor syndicate includes a number of well-known and highly-regarded biopharma venture capital investment firms, so that speaks well to the firm’s potential.
Metacrine is one of a growing number of firms that have gone public seeking funding to advance its pipeline of NASH treatment candidates.
I’ll provide a final opinion when we know more about the IPO’s pricing and valuation assumptions.
Expected IPO Pricing Date: To be announced.
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Disclosure: I/we have no positions in any stocks mentioned, and no plans to initiate any positions within the next 72 hours. I wrote this article myself, and it expresses my own opinions. I am not receiving compensation for it (other than from Seeking Alpha). I have no business relationship with any company whose stock is mentioned in this article.